Progress in Cardiovascular Diseases
Volume 53, Issue 1 , Pages 55-61, July 2010

Framingham Heart Study: The First 20 Years

  • Gerald M. Oppenheimer

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Gerald M. Oppenheimer, PhD, MPH, Associate Professor, Center for the History and Ethics of Public Health, Mailman School of Public Health, 722 West 168th Street, New York, NY 10032.

Brooklyn College and the Graduate Center, City University of New York

Center for the History and Ethics of Public Health, Mailman School of Public Health, Columbia University

Abstract 

The Framingham Heart Study remains the most famous and influential investigation in cardiovascular disease epidemiology. To generations of epidemiologists, it is a model for the cohort design. Here we revisit the origins of the Framingham Study before it became an accomplished and famous investigation whose existence and success are taken for granted.

When in 1947 the Public Health Service initiated the study, knowledge of the distribution and determinants of coronary heart disease was sparse. Epidemiology was primarily focused on infectious disorders. Framingham's pioneers struggled to invent an appropriate epidemiological approach to this chronic disease and to establish support for a new kind of research within a community. Thereafter they had to convince skeptical medical professionals that the results of epidemiological investigations of heart disease were applicable to their clinical practices.

Abbreviations and Acronyms: FHS, Framingham Heart Study, CVD, cardiovascular disease, PHS, Public Health Service, TB, tuberculosis, NHI, National Heart Institute, CHD, coronary heart disease, RCT, randomized controlled trial

Keywords: Framingham heart study, Public health service, Epidemiology, Cohort study, Cardiovascular disease, Disease causation, Controlled clinical trial

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 Statement of Conflict of Interest: see page 60.

PII: S0033-0620(10)00055-1

doi:10.1016/j.pcad.2010.03.003

Progress in Cardiovascular Diseases
Volume 53, Issue 1 , Pages 55-61, July 2010

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