Running as a Key Lifestyle Medicine for Longevity
Section snippets
Longevity benefits of running
There are several large population-based cohort studies, which have examined all-cause mortality and other health outcomes among runners compared with non-runners.17., 19., 20., 21., 22. Overall, these studies found that after adjusting for age and sex, runners have 30%–45% lower risk of all-cause mortality. After further controlling for smoking status, alcohol consumption, socioeconomic variables, body mass index (BMI), and other types of PA, the impact of running on reducing all-cause
Is running more important for longevity than other lifestyle and health risk factors?
The WHO has reported that 6% of premature mortality is related to physical inactivity.25 Another recent review indicated that physical inactivity causes 9% of all-cause mortality worldwide.1 Physical inactivity has been cited as the 4th leading global risk factor for death, especially in middle-to-high income countries, after high blood pressure (BP) (1st), cigarette smoking (2nd), and high blood glucose (3rd).25 Overweight/obesity and high cholesterol were found to be the 5th and 6th leading
Potential mechanisms linking running to health outcomes
There are many purported mechanisms through which running may reduce premature mortality (Fig 3). Numerous epidemiological studies have reported associations between running/vigorous exercise and improvements in various chronic disease risk factors, including HTN, dyslipidemia, body composition, insulin sensitivity, blood glucose regulation, disability, bone mineral density, and CRF.27., 28., 29., 30. Running/vigorous exercise may reduce some types of cancer-related mortality (e.g., breast and
Is running better than other types of PA for longevity?
One of the most commonly asked questions regarding PA and health is simply, “What type of exercise or PA is the best for health?” Likewise, because running is so popular and convenient, people are often curious about whether or not running is better than other types of exercise or PA. We conducted a simple joint stratification analysis to address this question using the Aerobics Center Longitudinal Study (ACLS) data. We dichotomized both leisure-time running and other PA except running into two
How much longer can runners live?
Most cohort studies automatically adjust for age in their analyses, but data from age-group separated analyses indicate that mortality outcomes are not only similar among young (<50 years) and old (≥50 years) runners, but that longevity benefits are clearly the greatest among those who continue to run throughout their lives.17., 19. Unfortunately, running participation declines with age. Twenty to 30% of 18–29 year olds indicate that they run or jog in their free time. Running participation
Is there too much running for longevity?
Some recent studies suggest that excessive endurance exercise (EEE), such as habitual running, may cause adverse effects on cardiac structure and function.27., 49., 50., 51., 52., 53. Some postulated mechanisms linking EEE to potential adverse cardiac effects include increased vascular oxidative stress and inflammation, myocardial fibrosis, and structural changes in the heart and its autonomic control.50., 54., 55., 56. A study on 52,755 participants in the Vasaloppet 90 km cross-country ski
Potential upper threshold for longevity benefits of running
It is too early to conclude that large amounts of running have adverse health effects. There is, however, benefit in providing a cut point for an effective and safe amount of running as a guide. We used the ACLS data62 to identify potential upper limits of running beyond which additional running provided no further mortality benefits, although there was also no excess risk of harm (Table 1).
These potential benefit thresholds are similar to findings from other large cohort studies on the
Conclusion
There is compelling evidence that running provides significant health benefits for the prevention of chronic diseases and premature mortality regardless of sex, age, body weight, and health conditions. There are strong plausible physiological mechanisms underlying how running can improve health and increase longevity. Running may be the most cost-effective lifestyle medicine from public health perspective, more important than other lifestyle and health risk factors such as smoking, obesity,
Statement of conflict of interest
None of the authors have any conflicts of interests with regard to this publication.
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Statement of Conflict of Interest: see page 53.